Giuliana Rancic has revealed she will undergo a double mastectomy, after being diagnosed with breast cancer in October.
The E! News presenter spoke openly about her decision during an interview on The Today Show.
America's popular morning show updated its Twitter feed today, saying: '"I'm going to go ahead and move forward with a double mastectomy." -@GiulianaRancic'.
In October, the 36-year-old initially underwent a double lumpectomy to removed cancerous growths in both breasts as well as her lymph nodes - but now she is taking extra measures after doctors failed to 'get all the cancer out'.
Husband Bill, who sat by his wife's side throughout the interview, explained that medics were unable to 'clear all the margins' and get all the cancer out, hence the final decision of double mastectomy.
He said: 'We were left with the decision, do you go back and do another lumpectomy and try to clean it out or go forward with a more radical procedure?'
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Giuliana even joked that the pair made a 'pros and cons list' to help them cement their decision.
She said her decision to have children played a part in making the decision, as otherwise she would have had to undergo another lumpectomy, radiation and two to five years of anti-oestrogen therapy, which would have put her into early menopause.
She said: 'To be honest, all it came down to was choosing to live and not looking over my shoulder for the rest of my life. It could have come back more aggressively next time, so for me it was just more important to get the cancer out.
'With the double mastectomy I now have less than one per cent chance of getting it back, otherwise it was 20, 30 or 40 per cent chance and for me it wasn't worth it.
Optimistic: E! News presenter said the love from her fans has kept her strong
'Bill said to me, "I just need you around for the next 50 years, kid. I don't care about the physical portion of this, so let's just get you healthy."'
Giuliana, speaking very calmly on the show, added: 'Bill's been the world to me through this, he brought some laughter to the process and reminded me who we are as a couple.
'It's made us stronger. I couldn't be more at peace with the decision. I still break down some nights when it's quiet in bed, it's easy to just start crying and be very sad, but I'm okay.'
Bill had a positive outlook, saying: 'I'm focused on the finished line, we'll be done with this by Christmas time and then we don't look back..'
During her return to work last month, Rancic said she owed her inner strength to the influx of support from her fans.
Family on hold: The couple will wait until Giuliana has recovered before embarking on IVF again
She told Parade magazine: 'I'm good. I'm hanging in there. I have good days and bad days, but so far good.
'I'm very optimistic and I'm just happy to have caught it early. I think that's really the most important thing. Early detection means so much.'
Rancic discovered her tumour in its early stages during a doctor-recommended mammogram while undergoing in vitro fertilisation.
Having married entrepreneur Bill, who shot to fame on The Apprentice USA, in September 2007, the pair have made several attempts to have a child.
Conquering the disease: The Today show featured snapshots of Giuliana's stay in hospital
Loving couple: After appearing on The Today Show Giuliana and Bill Rancic were seen returning to their Manhattan hotel
However, they experienced problems with conceiving and doctors recommended that Giuliana gain weight to increase their chances.
By 2010 she had put on five pounds, before embarking on IVF that March.
Sadly, despite falling pregnant in the spring, Giuliana suffered a miscarriage at eight weeks.
The couple have now decided to put a family on hold until Giuliana has made a full recovery.
Road to recovery: Giuliana will undergo a double mastectomy in a bid to ensure cancer won't return